The autumn chill settled over Shanghai as 26-year-old Yutong stepped into the consultation room, her knuckles white around an ultrasound report. Newly married and dreaming of a family, she faced a diagnosis that shattered her world: stage I endometrial cancer. “Doctor,” she whispered, tears brimming, “I thought cancer only happened to older women.”

    Across the desk, Dr. Lu Wen, Chief of Gynecology at Shanghai First Maternity and Infant Hospital, studied the numbers that told a deeper story—uncontrolled metabolic chaos beneath the surface. Yutong’s insulin resistance had skyrocketed to five times normal levels; her testosterone had doubled. At 5’3" and 187 pounds, her body was silently screaming for help.

    “I know you’ve been told removal of your uterus is the only option,” Dr. Lu said gently, “but what if we try something revolutionary first?” She proposed a bold three-pronged approach: metformin to starve cancer cells of sugar, progesterone to reverse malignant growth, and a medically supervised metabolic reset with one non-negotiable goal—lose 33 pounds in three months.

    The treatment tested every ounce of Yutong’s resilience. Early progesterone therapy swelled her body to 227 pounds, transforming her reflection into what she tearfully described as “a stuffed cushion.” “Your cells aren’t failing—they’re reprogramming,” Dr. Lu reassured her during dark moments, gripping her hand. “Stay in the fight.”

    When the fourth hysteroscopy revealed vanished cancer cells and her weight settled at 176 pounds, the hospital corridor echoed with something rare in oncology wards: the sound of a woman laughing through happy tears.

    The science behind her healing proved groundbreaking. “We essentially negotiated with the cancer,” Dr. Lu later explained. “Metformin cut off its fuel supply while progesterone coerced malignant cells to revert to normal—like rehabilitating criminals instead of executing them.” Research confirmed their approach: obese early-stage patients like Yutong saw nearly 70% remission rates when combining the drugs.

    But the real miracle began in summer 2024, when two pink lines appeared on a pregnancy test. Medical teams transformed into cheerleaders through every milestone—normal genetic screening at 12 weeks, perfect glucose tolerance at 24 weeks. On the day of her C-section(cesarean section), two dozen clinicians held their breath until the surgeon announced: “Endometrial tissue clear. Baby girl arriving now.”

    As her daughter’s first cry pierced the OR, Yutong traced a trembling finger over downy skin untouched by cancer’s shadow. “Welcome,” she breathed into the warmth of her baby’s forehead, tears christening new life, “to the miracle science helped write.”

    In that sacred space between surgical lights and swaddling blankets, a narrative of fear became a testament to courage—where medical innovation and human tenacity conspired to turn impossible hopes into living, breathing proof of healing.

/ A physician from Shanghai First Maternity and Infant Hospital comments /

    "Yutong’s case is a typical paradigm shift in the treatment of gynecological cancers. Today, metabolic regulation has emerged as a groundbreaking target in cancer therapy, fertility preservation has transitioned from an optional consideration to a core element of treatment, and multidisciplinary collaboration—integrating gynecologic oncology, reproductive medicine, and obstetrics—has significantly enhanced clinical outcomes. At our hospital, the “Metabolic-Immune-Hormonal” triple therapy has achieved pathological complete remission in over 30 early-stage endometrial cancer patients, with more than 10 of them successfully conceiving and carrying pregnancies to term."

⚠️ Young women should be vigilant for the following symptoms, which may indicate endometrial abnormalities:

• Menstrual cycles shorter than 21 days or longer than 35 days

• Non-menstrual bleeding lasting more than 3 months

• A body mass index (BMI) over 28, accompanied by hirsutism or  acne

✅ "We recommend annual transvaginal ultrasound evaluations and cervical screenings to monitor and detect potential issues early."

This approach not only saves lives but also empowers women to preserve their dreams of motherhood—a testament to the power of innovation and compassion in modern medicine.

Doctor Introduction: 

Dr.Lu Wen

 If you'd like to contact to Dr. Lu Wen, you also can email us with ChenQing@ShanghaiDoctor.cn